Rephetio: Repurposing drugs on a hetnet
Daniel Himmelstein, Antoine Lizee, Chrissy Hessler, Leo Brueggeman, Sabrina Chen, Dexter Hadley, Ari Green, Pouya Khankhanian, Sergio Baranzini
Welcome to project Rephetio. We aim to predict the probability that a given approved small molecule will treat a given complex disease. First, we construct a hetnet for drug repurposing. The network integrates 29 public resources and contains 47 thousand nodes (of 11 types) and 2.3 million edges ...