Digital craftsman of the biodata revolution and pioneer of data integration for human health.

Projects

Daniel Himmelstein, Antoine Lizee, Chrissy Hessler, Leo Brueggeman, Sabrina Chen, Dexter Hadley, Ari Green, Pouya Khankhanian, Sergio Baranzini

Report published

Welcome to project Rephetio. We aim to predict the probability that a given approved small molecule will treat a given complex disease. First, we construct a hetnet for drug repurposing. The network integrates 29 public resources and contains 47 thousand nodes (of 11 types) and 2.3 million edges ...

Discussion participating

27	How should we construct a catalog of drug indications? [rephetio] July 8, 2017
3	Assessing the effectiveness of our hetnet permutations [rephetio] July 8, 2017
3	Hosting Hetionet in the cloud: creating a public Neo4j instance [rephetio] May 17, 2017
15	Tracking project reuse, citation, and publicity [rephetio] May 2, 2017
9	Using the neo4j graph database for hetnets [rephetio] April 27, 2017
46	Report Review: Rephetio: Repurposing drugs on a hetnet [rephetio] April 10, 2017
6	Our hetnet edge prediction methodology: the modeling framework for Project Rephetio [rephetio] March 13, 2017
3	Why we predicted ictogenic tricyclic compounds treat epilepsy? [rephetio] March 10, 2017
5	Measuring user contribution and content creation [rephetio] Feb. 8, 2017
6	One network to rule them all [rephetio] Feb. 4, 2017

View all 135 discussions

Publications

Comments	Title	Year
0	Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis	2016
0	Genetic Association–Guided Analysis of Gene Networks for the Study of Complex Traits	2016
0	Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis	2016
0	Qualifying Exam proposal: Drug repurposing on a heterogeneous network of pathogenesis	2016
0	iCTNet2: integrating heterogeneous biological interactions to understand complex traits	2015
0	iCTNet2: integrating heterogeneous biological interactions to understand complex traits	2015
0	Heterogeneous Network Edge Prediction: A Data Integration Approach to Prioritize Disease-Associated Genes	2015
0	Understanding multicellular function and disease with human tissue-specific networks	2015
0	Lung cancer incidence decreases with elevation: evidence for oxygen as an inhaled carcinogen	2015
0	Evolving hard problems: Generating human genetics datasets with a complex etiology	2011

View all 14 publications

Connect with Daniel

dhimmel.com

Stats

Impact points	2214
Est. earnings	$454
Proposals	1
Comments	520
Comments rated	200
Annotations	69

Interests

Heterogeneous Networks Statistics Genomics Machine learning Networks Algorithms Biostatistics Bioinformatics Biomedical Informatics Computer Science Computational Biology Terminologies Network Biology