Got taught Maths and Physics, enjoyed Neuroscience in grad school, now working on building smart stuff for clinicians with algorithms and data.

Projects

Rephetio: Repurposing drugs on a hetnet

Daniel Himmelstein, Antoine Lizee, Chrissy Hessler, Leo Brueggeman, Sabrina Chen, Dexter Hadley, Ari Green, Pouya Khankhanian, Sergio Baranzini

Report published

Welcome to project Rephetio. We aim to predict the probability that a given approved small molecule will treat a given complex disease. First, we construct a hetnet for drug repurposing. The network integrates 29 public resources and contains 47 thousand nodes (of 11 types) and 2.3 million edges ...

Discussion participating

27	How should we construct a catalog of drug indications? [rephetio] July 8, 2017
5	Measuring user contribution and content creation [rephetio] Feb. 8, 2017
16	Discussion summary statistics for illustrating project impact [meta] Aug. 8, 2016
1	Share single posts [meta] May 3, 2016
5	Computing standardized logistic regression coefficients [rephetio] May 2, 2016
6	Transforming DWPCs for hetnet edge prediction [rephetio] April 16, 2016
8	Estimating the complexity of hetnet traversal [rephetio] April 16, 2016
2	Network Edge Prediction: Estimating the prior [rephetio] April 15, 2016
15	Support (and enforce) ssl connections to Thinklab [meta] April 15, 2016
4	Network Edge Prediction: how to deal with self-testing [rephetio] April 14, 2016

View all 21 discussions

Publications

Comments	Title	Year
0	Multidimensional reduction of multicentric cohort heterogeneity: An alternative method to increase statistical power and robustness	2016
0	Long-term evolution of multiple sclerosis disability in the treatment era	2016
0	Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis	2016
0	Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis	2016
0	Genetic contribution to multiple sclerosis risk among Ashkenazi Jews	2015
0	Haplotype-based approach to known MS-associated regions increases the amount of explained risk	2015
0	Precision medicine in chronic disease management: The multiple sclerosis BioScreen	2014

View all 7 publications

Connect with Antoine

Stats

Impact points	554
Est. earnings	$251
Proposals	1
Comments	39
Comments rated	28
Annotations	0

Interests

Genomics Machine learning